Orchard Therapeutics plc

NASDAQ

ORTX

Stock

Yield per half year: 0%
Dividend yield: 0%
Sector: Healthcare

Reporting Orchard Therapeutics plc

Capitalization

IFRS

Reporting Annual Quarterly

	2016	2017	2018	2019	2020	2021	2022	2023	LTM	Average for 5 years	CAGR 5
Capitalization, bln $			0.3795	1.46	1.36	0.133	0.0697	0.1604	0.112	0.6366	-35.71
Revenue, bln $			0.0021	0.0025	0.0026	0.000483	0.007	0.0218	0.0218	0.0069	54.21
Net profit, bln $	-0.019	-0.04	-0.2305	-0.1634	-0.152	-0.0363	-0.0079	-0.0729	-0.0729	-0.0865	-14.91
EV, bln $			2.6	1.3	0.0473	0.0183	0.0369	-0.0097	0.0369	0.2786	-137.55
EBIT, bln $	-0.0192	-0.0385	-0.2295	-0.1729	-0.157	-0.0364	-0.0316	0.0375	-0.0316	-0.0721	-173.66
EBITDA, bln $	-0.0192	-0.0382	-0.2283	-0.1641	-0.1484	-0.0355	-0.0081	-0.0062	-0.0081	-0.0725	-48.07
OIBDA $				-0.1736	-0.1534	-0.0356	-0.0318			-0.0986	-34.58
Book value, bln $	-0.0197	-0.0594	0.3113	0.2992	0.1784	0.21	0.0983	0.0983	0.0983	0.1768	-19.96
FCF, bln $	-0.015	-0.034	-0.1016	-0.1705	-0.1389	-0.1283	-0.0825	-0.0944	-0.0944	-0.1229	-11.15
Operating Cash Flow, bln $	-0.0146	-0.0325	-0.0975	-0.1661	-0.1263	-0.1251	-0.076	-0.0933	-0.0933	-0.1174	-10.89
Operating profit, bln $	-0.019	-0.039	-0.235	-0.1729	-0.157	-0.0364	-0.0316	-0.102	-0.102	-0.1000	-10.02
Operating expenses, bln $	0.0192	0.0385	0.2367	0.1746	0.1587	0.0369	0.0361	0.1239	0.1239	0.1060	-6.63
CAPEX, bln $	0.00019	0.002	0.004	0.0044	0.0127	0.0032	0.0065	0.0011	0.0011	0.0056	-24.21

	2020Q4	2021Q2	2021Q3	2021Q4	2022Q1	2022Q2	2022Q3	2022Q4	2023Q1	2023Q2	2023Q3	2023Q4	Average for 5 quarters	CAGR 5
Capitalization, bln $			0.0379	0.0211	0.0125	0.0072	0.0071	0.0057	0.0243	0.0965	0.1237	0.3596	0.1220	129.08
Revenue, bln $	0		0.0012	0.000483	0.0055	0.0044	0.0058	0.007	0.0012	0.0073	0.0063		0.0055	1.67
Net profit, bln $		-0.0365	-0.0363	-0.0347	-0.0443	-0.0509	-0.0476	0.1349	-0.0174	-0.0123	-0.0353		0.0045	-5.80
EV, bln $		0.0112	0.0046	0.1231	0.0996	0.0776	0.04	0.0369	0.0637	0.1112	0.1924		0.0888	36.91
EBIT, bln $		-0.036	-0.0327	-0.0372	-0.0376	-0.0324	-0.0255	-0.0316	-0.0263	-0.0226	-0.0216		-0.0255	-3.27
EBITDA, bln $		-0.0572	-0.0378	-0.0365	-0.0429	-0.0498	-0.0472	-0.0309	-0.0197	-0.0195	-0.021		-0.0277	-14.95
OIBDA $							-0.0251	-0.1974	-0.0285	-0.0298	-0.0072		-0.0576	-22.10
Book value, bln $		-0.6774	-0.7139	0.21	0.1756	0.1463	0.1237	0.0983	0.1017	0.109	0.0803		0.1026	-8.28
FCF, bln $		-0.0362	-0.0167	-0.0329	-0.02	-0.0276	-0.0224	-0.0126	-0.03	-0.0278	-0.024		-0.0234	1.39
Operating Cash Flow, bln $		-0.0361	-0.0164	-0.0334	-0.0196	-0.0264	-0.0179	-0.0121	-0.0295	-0.0278	-0.0239		-0.0222	5.95
Operating profit, bln $		-0.0356	-0.0157	-0.0372	-0.0376	-0.0324	-0.0255	-0.0316	-0.0263	-0.0226	-0.0216		-0.0255	-3.27
Operating expenses, bln $		0.036	0.0339	0.0371	0.0415	0.0357	0.0312	0.0386	0.0275	0.0299	0.0279		0.0310	-2.21
CAPEX, bln $		0.000499	0.000645	0.000494	0.000398	0.0012	0.0045	0.000484	0.000514	0.0000	0.000126		0.0014	-36.29

	Average for 5 quarters	CAGR 5

Cash flow Cash flow quarterly Assets

Balance sheet

IFRS

Reporting Annual Quarterly

	2016	2017	2018	2019	2020	2021	2022	2023	LTM	Average for 5 years	CAGR 5
Cash, bln $	0.0035	0.0899	0.3358	0.0191	0.0551	0.0559	0.0684	0.0684	0.0684	0.0534	29.06
Short-Term Investments $				0.3059	0.1368	0.1642	0.0753	0.1125	0.0753	0.1589	-18.13
Accounts Receivable $	0.0000	0.0012	0.0127	0.0164	0.0182	0.0322	0.0144		0.0144	0.0188	2.54
Total Current Assets $	0.004	0.0942	0.3555	0.3499	0.2235	0.2753	0.1681	0.1813	0.1681	0.2396	-12.32
Net assets, bln $	-0.0165	0.0864	0.3555	0.3499	0.2235	0.2753	0.0309	0.1681	0.1681	0.2095	-13.64
Assets, bln $	0.0043	0.0973	0.366	0.3993	0.2809	0.3224	0.2189	0.2189	0.2189	0.2881	-11.33
Short-Term Debt $				0.0059	0.0138	0.0081	0.0159	0.016	0.0159	0.0119	22.08
Long-Term Debt $				0.0247	0.0202	0.0321	0.023	0.0184	0.023	0.0237	-5.72
Liabilities, bln $	0.0208	0.0109	0.0547	0.1001	0.1025	0.1125	0.1206	0.1206	0.1206	0.1113	3.80
Net debt, bln $	-0.0035	-0.0899	-0.3358	0.0269	0.003	0.0036	-0.0103	-0.0103	-0.0103	0.0026	-182.53
Debt, bln $				0.0459	0.0582	0.0595	0.0581	0.0581	0.0581	0.0560	4.83
Interest Income $	0		0.0011	0.0074	0.0032	0.000412	0.000857	0.0048		0.0033	-8.29
Interest Expense, bln $		0.0015	0.0015	0.0015	0.0023	0.000683	0.000933	0.0038	0.0038	0.0018	20.43
Net interest income, bln $	0		0.0011	0.0074	0.0032	0.000412	0.000857	0.0048	0.0048	0.0033	-8.29
Amortization, bln $	0	0.000302	0.0012	0.0087	0.0086	0.000874	0.0235			0.0086	81.29
Cost of production, bln $			0.000422	0.000805	0.000857	0.000226	0.0024	0.0067	0.0067	0.0022	52.78
Inventory $					0.000665	0.002	0.0034	0.0069	0.0034	0.0032	79.48

	2020Q4	2021Q1	2021Q2	2021Q3	2021Q4	2022Q1	2022Q2	2022Q3	2022Q4	2023Q1	2023Q2	2023Q3	Average for 5 quarters	CAGR 5
Cash, bln $			0.0999	0.0743	0.0559	0.0608	0.0535	0.0808	0.0684	0.0615	0.0383	0.0235	0.0545	-21.89
Short-Term Investments $			0.1694	0.1798	0.1642	0.1382	0.1174	0.0658	0.0753	0.0848	0.1125	0.1019	0.0881	9.14
Accounts Receivable $			0.0218	0.025	0.0367	0.021	0.0188	0.0191	0.0144	0.0081	0.0181	0.0144	0.0148	-5.49
Total Current Assets $			0.3042	0.2915	0.2753	0.2374	0.2053	0.1793	0.1681	0.1662	0.1813	0.1539	0.1698	-3.01
Net assets, bln $	0.0346	0.2956	0.2644	0.2413	0.2753	0.2374	0.2053	0.0309	0.0309		0.0288		0.1067	-34.42
Assets, bln $			0.3648	0.3557	0.3224	0.2915	0.2592	0.2341	0.2189	0.217	0.2323	0.2023	0.2209	-2.88
Short-Term Debt $			0.0082	0.0083	0.0081	0.0102	0.0122	0.0141	0.0159	0.0159	0.016	0.015	0.0154	1.25
Long-Term Debt $			0.0327	0.0328	0.0321	0.0298	0.0275	0.0253	0.023	0.0207	0.0184	0.0162	0.0207	-8.53
Liabilities, bln $			0.1004	0.1144	0.1125	0.1159	0.1129	0.1103	0.1206	0.1154	0.1233	0.122	0.1183	2.04
Net debt, bln $			-0.0384	-0.0135	-0.0285	0.0000	0.0064	-0.0223	-0.0103	-0.0082	0.0122	0.0244	-0.0008	-201.82
Debt, bln $			0.041	0.0443	0.0274	0.0608	0.0599	0.0585	0.0581	0.0366	0.0505	0.0478	0.0503	-3.96
Interest Income $			0.000113	0.0001	0.0001	0.0001	0.000213	0.000404	0.000171	0.001	0.0014	0.0015	0.0009	30.00
Interest Expense, bln $			0.000593	0.000683	0.000683	0.000675	0.000672	0.000799	0.0012	0.000957	0.000975	0.000932	0.0010	3.13
Net interest income, bln $			0.000113	0.0001	0.0001	0.0001	0.000213	0.000404	0.000171	0.001	0.0014	0.0015	0.0009	30.00
Amortization, bln $			0.000508	0.000648	0.000676	-0.0053	-0.0174	-0.0217	0.000721	0.0066	0.003	0.000652	-0.0021	-149.61
Cost of production, bln $	0	0		0.000226		0.0016	0.0011	0.0016	0.0024	0.000367	0.0022	0.0017	0.0017	1.22
Inventory $			0.0016	0.0017	0.002	0.0018	0.0019	0.0023	0.0034	0.0056	0.0069	0.0066	0.0050	23.47

	Average for 5 quarters	CAGR 5

Share

IFRS

Reporting Annual Quarterly

	2016	2017	2018	2019	2020	2021	2022	2023	2024	2025	LTM	Average for 5 years	CAGR 5
EPS	-1.89	-3.94	-10.22	-17.53	-15.28	-2.93	-0.6148	-61.6			-0.6148	-19.5910	28.58
Share price			17.25	15.73	13.75	4.32	0.4599	16.45	16.7	16.7	16.7	10.93	31.05
Number of shares, mln	10	8	22	93	99	12	12.82	22.84			12.82	47.93	-24.48
FCF/share	-1.48	-3.78	-4.5	-18.29	-13.97	-10.35	-6.43	-644.66			-6.43	-138.7400	103.90

	2021Q2	2021Q3	2021Q4	2022Q1	2022Q2	2022Q3	2022Q4	2023Q1	2023Q2	2023Q3	2023Q4	Average for 5 quarters	CAGR 5
EPS	-0.29	-0.28	-0.2724	-3.47	-3.98	-3.71	10.52	-1.23	-0.6502	-1.55		0.6760	-16.02
Share price		2.97	1.65	0.9797	0.5642	0.5566	0.4421	1.71	5.1	5.42	15.75	5.68	104.34
Number of shares, mln		12.74	12.76	12.77	12.79	12.81	12.82	14.18	18.93	22.84	22.84	18.32	12.24
FCF/share	-0.291	-0.1438	-0.2583	-1.57	-2.15	-1.75	-0.9802	-2.12	-1.47	-1.05		-1.4740	-9.71

	Average for 5 quarters	CAGR 5

Efficiency

IFRS

Reporting Annual Quarterly

	2016	2017	2018	2019	2020	2021	2022	2023	2024	2025	LTM	Industry average	Average for 5 years	CAGR 5
ROE, %	115.5	-113.75	-115.9	-53.53	-63.64	-18.72	-5.12	-5.12			-5.12	17.60	-29.2260	-37.46
ROA, %	-445.6	-78.25	-99.49	-42.71	-44.69	-12.05	-2.91	-2.91			-2.91	5.71	-21.0540	-41.57
ROIC, %			-174.83	-46.54	-52.55	-56.48					-51.67	17.65	-82.6000	-24.61
ROS, %			-11056.12	-6531	-5795.07	-8532.24	-112.84	-333.9	-333.9	-333.9	-333.9	13.36	-1929.3560	-47.70
ROCE, %	116.21	-44.57	-72.15	-50.34	-68.44	-13.02	-19.95	23.67		-32.15	-32.15	29.73	-21.9780	-14.02
EBIT margin				-6879.15	-6049.25	-7539.34	-452.22			-144.7	-144.7	18.53	-4212.9320	-53.81
EBITDA margin			-10998.36	-6531	-5717.84	-7358.39	-115.65	-88.26		-37.09	-37.09	26.10	-2663.4460	-63.49
Net margin			-11102.84	-6503.06	-5856.61	-7525.67	-112.84	-333.9			-333.9	13.36	-4066.4160	-44.78
Operational efficiency, %			-11321.34	-6879.15	-6049.25	-8384.06	-452.22	-467.13	-467.13	-467.13	-467.13	16.64	-2047.5340	-43.87
FCF yield, %			-79.34	-118.37	-187.38	-234.64	-1014.51	-58.87					-322.7540	-13.04

	2020Q4	2021Q2	2021Q3	2021Q4	2022Q1	2022Q2	2022Q3	2022Q4	2023Q1	2023Q2	2023Q3	2025Q2	2025Q3	Industry average	Average for 5 quarters	CAGR 5
ROE, %		-15.8	-15.14	-13.94	-18.63	-24.47	-26.63	89.97	-17.13	-10.91	-34.38			17.60	0.1840	5.24
ROA, %		-9.71	-10.12	-10.23	-14.43	-18.49	-19.29	59.56	-8.02	-5.48	-16.25			5.71	2.10	-3.37
ROS, %				-7525.47	-801.88	-1165.66	-823.35	1930.92	-1407.6	-168.27	-560.44	-333.9	-333.9	13.36	-560.8220	-25.01
ROCE, %				-11.85	-12.97	-12.4	-11.09	-15.85	-25.83	-13.26	-13.3	-32.15	-32.15	29.73	-23.3380	4.47
EBIT margin							-440.83	-452.22	-2122.72	-308.48	-342.83	-144.7	-144.7	18.53	-612.6860	-41.56
EBITDA margin				-7561.28	-775.78	-1140.25	-816.96	-441.9	-1590.62	-266.79	-332.48	-37.09	-37.09	26.10	-452.8140	-52.84
Net margin	-1681000		-3057.47	-7182.61	-801.88	-1165.66	-823.35	1930.92	-1407.6	-168.27	-560.44			13.36	-205.7480	-7.40
Operational efficiency, %				-7539.34	-680.3	-742.88	-440.83	-452.22	-2122.72	-308.48	-342.83	-467.13	-467.13	16.64	-741.6580	-26.12
FCF yield, %		-52.23	-48.33	-160.17	-159.84	-381.9	-313.86	-221.75	-123.63	-28.82	-19.41				-141.4940	-42.69

	Industry average	Average for 5 quarters	CAGR 5

Coefficients

IFRS

Reporting Annual Quarterly

	2017	2018	2019	2020	2021	2022	2023	2024	2025	LTM	Industry average	Average for 5 years	CAGR 5
P/E		-8.69	-10.72	-3.62	-1.16	-1.03	1.64				69.12	-2.9780	-168.70
P/BV		9.44	4.27	0.248	0.0703	0.4803	0.0066			0.4803	8.87	1.02	-72.60
P/S		1415.94	508.31	17.05	30.54	6.76	0.0927			6.76	8.05	112.55	-82.13
P/FCF		-19.73	-10.27	-3.96	-1.32	-0.0986	-1.36	-1.19	-1.19	-1.19	8.97	-1.0317	-2.05
E/P		-1.8	-1.13	-2.05	-0.6646	-0.9694	-0.4547	-0.6511	-0.6511	-0.6511	0.03	-0.6782	-0.41
EV/EBIT			-7.54	-0.3012	-0.5032	-1.17		-1.17	-1.17	-1.17	88.11	-0.8629	31.18
EV/EBITDA	2.35	-11.4	-7.95	-0.3187	-0.5156	-4.56	1.57			-4.56	53.63	-2.3549	-172.29
EV/S			61.91	20.43	80.72	5.28	5.27	1.69	1.69	1.69	8.36	18.93	-53.85
EV/FCF			-0.9125	-0.3815	-0.3038	-0.4468		-0.3908	-0.3908	-0.3908	21.77	-0.3827	0.48
Debt/EBITDA			-0.2826	-0.17	-0.1949	-7.19	-7.17	-7.17	-7.17	-7.17	2.61	-5.7790	105.66
Netdebt/Ebitda	2.35	1.47	-0.03	0.14	0.11	1.28	1.27	1.27	1.27	1.27	0.49	1.04	63.11
Debt/Ratio		0.15	0.25	0.36	0.35	0.2654	0.2654	0.2654	0.2654	0.2654	0.24	0.2823	-5.38
Debt/Equity		0.18	0.33	0.57	0.54	0.5912	0.3456	0.3456	1.23	1.23	2.82	0.6105	17.90
Debt/Net Income			-0.1872	-0.2237	-1.11	-7.37	-7.35	-0.7968	-0.7968	-0.7968	10.75	-3.4847	-6.42
PEG									0	0	-67.37
Beta				1.2	1.18	0.86	14.18	0	0	0	-0.03	4.35	85.41
Altman Index		19.81	8.44	-0.82	-1.63	5016.33	-12.74	-12.02	-12.02	-12.02	12.59	995.58	49.12

	2020Q4	2021Q2	2021Q3	2021Q4	2022Q1	2022Q2	2022Q3	2022Q4	2023Q1	2023Q2	2023Q3	2025Q1	2025Q2	2025Q3	Industry average	Average for 5 quarters	CAGR 5
P/E		-1.92	-1.04	-0.5804	-0.2824	-0.1417	-0.15	-5.73	-1.39	-7.84	-3.5				69.12	-3.7220	87.76
P/BV		0.2654	0.157	0.722	0.5671	0.4868	0.5033	0.4803	0.7073	0.9078	2.09				8.87	0.9377	32.94
P/S	22007.94		245.78	90.49	17.5	7.07	3.85	2.08	3.56	3.56	5.69				8.05	3.75	8.13
P/FCF				-0.6243	-0.6256	-0.2618	-0.3186	-0.451	-0.8089	-3.47	-5.15		-1.19	-1.19	8.97	-2.3618	8.03
E/P				-1.72	-3.54	-7.06	-6.67	23.8	-0.717	-0.1276	-0.2855		-0.6511	-0.6511	0.03	-0.4865	-1.91
EV/EBIT							-1.57	-1.17	-2.43	-4.93	-8.91		-1.17	-1.17	88.11	-3.7220	-13.60
EV/EBITDA		-4.28	-2.05	-0.8754	-0.6625	-0.4692	-0.2276	-0.2159	-3.24	-0.9487	-2.11				53.63	-1.3484	56.11
EV/S				11.16	-1.5	-1.5	6.92	-3.42	51.48	15.21	30.54		1.69	1.69	8.36	20.12	-49.50
EV/FCF				-0.1595	0.4134	0.2376	-1.79	1.9	-2.12	-4	-8.01		-0.3908	-0.3908	21.77	-2.9823	-28.69
Debt/EBITDA				-0.7502	-1.42	-1.22	-1.3	0.4342	-1.86	-2.59	-2.28		-7.17	-7.17	2.61	-4.2140	30.98
Netdebt/Ebitda				-0.1	-0.00049	-0.1289	0.4725	0.3347	0.4176	-0.6273	-1.16		1.27	1.27	0.49	0.2341	24.91
Debt/Ratio				0.1247	0.1372	0.1532	0.1682	0.1774	0.1687	0.2174	0.2364		0.2654	0.2654	0.24	0.2307	9.49
Debt/Equity				0.1915	0.2277	0.2715	0.3183	0.3953	0.3602	0.4632	0.5958		1.23	1.23	2.82	0.7758	27.84
Debt/Net Income				-1.11	-0.903	-0.7799	-0.8277	0.288	-2.1	-4.1	-1.35		-0.7968	-0.7968	10.75	-1.8287	-17.62
Beta												0	0		-0.03
Altman Index			-1.69	4.44	908.57	2.05	-1.72	-1.33		1.59		-12.02	-12.02	-12.02	12.59	-7.1600	55.31

Dividends

IFRS

Reporting Annual

	2018	2019	2020	2021	2022	2023	LTM	Industry average	Average for 5 years	CAGR 5
Dividend							0
Dividend yield, %	0	0	0	0	0	0	0	1.71
Dividends / profit, %			0	0	0		0	155.02

	Industry average	Average for 5 quarters	CAGR 5

	Industry average	Average for 5 quarters	CAGR 5

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Other

IFRS

Reporting Annual Quarterly

	2018	2019	2020	2021	2022	2023	CAGR 5
Total Debt	0.0479	0.0559	0.0516				2.51
CAPEX/Revenue, %		173.78	488.17	669.77	93.24	5	-50.82
Staff, people				224	224	166	-9.51

	2022Q3	2022Q4	2023Q1	2023Q2	2023Q3	CAGR 5
CAPEX/Revenue, %	77.17	6.93	41.55	0.4238	2	-51.84

	CAGR 5